abstract：:Endothelial cells synthesize and release different proteins involved in their function, and some of these proteins may play important roles in the cellular response to injury, infection, or glucocorticoids. We have examined the profile of proteins released from rabbit coronary microvascular endothelial (RCME) and huma...

journal_title：Thrombosis research

authors： Partridge CA,Gerritsen ME

更新日期：1990-01-01 00:00:00

abstract：:Endothelial cells in biopsied blood vessels from von Willebrand factor (vWf)-deficient Doberman pinscher dogs contain immunologically detectable vWf. These dogs and normal dogs were treated with DDAVP (0.6 microgram/kg) and epinephrine (0.5 microgram/kg/min for 30 minutes) and were exercised, using 5 different exercis...

journal_title：Thrombosis research

authors： Meyers KM,Wardrop KJ,Dodds WJ,Brassard J

更新日期：1990-01-01 00:00:00

abstract：:Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...

journal_title：Thrombosis research

authors： Fukui H,Kamitsuji H,Nagao T,Yamada K,Akatsuka J,Inagaki M,Shike S,Kobayashi Y,Yoshioka K,Maki S

更新日期：1989-12-15 00:00:00

abstract：:An in vitro model of platelet adhesion, the annular perfusion chamber, was utilized to test the effects of Interleukin 1 on vascular thrombogenicity for platelets. De-endothelialized, everted human umbilical arteries were placed in cell culture media with or without Interleukin 1. The arteries were later perfused with...

journal_title：Thrombosis research

authors： Schorer AE,White JG

更新日期：1989-11-15 00:00:00

abstract：:The two objectives of the study were to determine whether a procedure could be developed for measuring cancer procoagulant (CP) activity in human serum and if this procedure provided a method for distinguishing people with cancer from those without cancer. A procedure was developed for processing human serum such that...

journal_title：Thrombosis research

authors： Gordon SG,Benson B

更新日期：1989-11-01 00:00:00

abstract：:A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...

journal_title：Thrombosis research

authors： Contant G,Martinoli JL

更新日期：1989-11-01 00:00:00

abstract：:Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...

journal_title：Thrombosis research

authors： Nakano T,Hanasaki K,Arita H

更新日期：1989-10-15 00:00:00

abstract：:Cell lysates of the human monoblastic leukemia cell line, THP-1, have procoagulant activity (PCA) that is Ca++-dependent and not demonstrable in either Factor VII-, or Factor X-deficient plasma. The PCA of THP-1 cells was enhanced by human recombinant tumor necrosis factor-alpha (TNF-alpha) up to five fold. There was ...

journal_title：Thrombosis research

authors： Tanaka M

更新日期：1989-10-15 00:00:00

abstract：:Using the standard turbidimetric method of platelet aggregation and quantitation of platelet secretion with 14C-Serotonin, we have examined the responsiveness of the platelets of mongrel dogs to arachidonic acid (AA), and the thromboxane agonist U46619 in the presence and absence of a subthreshold concentration of epi...

journal_title：Thrombosis research

authors： McGoff MA,Allen BT,Der T,Sicard GA,Santoro SA

更新日期：1989-09-15 00:00:00

abstract：:Treatment of deep venous thrombosis with low molecular weight heparin (LMWH-Novo, Logiparin) was carried out with two different doses of Logiparin, 75 XaI U/kg b.w. twice daily and 150 XaI U/kg b.w. once daily subcutaneously for 5 days. Simultaneously warfarin was given from the first day of heparin treatment. Mean ag...

journal_title：Thrombosis research

authors： Siegbahn A,Y-Hassan S,Boberg J,Bylund H,Neerstrand HS,Ostergaard P,Hedner U

更新日期：1989-09-15 00:00:00

abstract：:The concentration of tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) and the complex of t-PA and PAI-1 (t-PA-PAI-1 complex) were measured using an enzyme immunoassay, where the first antibody was monoclonal antibody against PAI-1 and the second one was polyclonal anti-t-PA Fab' antibody....

journal_title：Thrombosis research

authors： Takada Y,Takada A

更新日期：1989-09-01 00:00:00

abstract：:Twenty-five men and 26 women were studied to investigate the effects of acute strenuous exercise on hemostasis after obtaining their informed consent. After familiarization, they performed exercise on a bicycle ergometer at 75% of their predetermined maximal workload until exhaustion. Bleeding time, measured by the Si...

journal_title：Thrombosis research

authors： Chen HI,Tang YR,Wu HJ,Jen CJ

更新日期：1989-08-15 00:00:00

abstract：:The ability of parenteral heparin to release the capillary-bound enzymes lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) into the circulation is shared by several other sulphated polysaccharides. The lipase-releasing activity in rats of two unfractionated heparins has been compared with that of charact...

journal_title：Thrombosis research

authors： Williams SP,Johnson EA

更新日期：1989-08-01 00:00:00

abstract：:The levels of protein C (PC) and other coagulation factors were monitored during endotoxin-induced disseminated intravascular coagulation (DIC) in the dog. Initial evaluation of the effectiveness of intradermal administration of bolus endotoxin quantities into the dog, demonstrated induction of DIC in the canine, with...

journal_title：Thrombosis research

authors： Madden RM,Ward M,Marlar RA

更新日期：1989-08-01 00:00:00

abstract：:Bovine hide collagen dispersions were swollen in the pH range 1.6-7.0, treated with glutaraldehyde, and dialyzed to neutral pH. The intensity with which these collagens reacted with human platelets in plasma was studied by aggregometry and scanning electron microscopy. Collagen swollen at a pH below 4.25 +/- 0.30 and ...

journal_title：Thrombosis research

authors： Sylvester MF,Yannas IV,Salzman EW,Forbes MJ

更新日期：1989-07-01 00:00:00

abstract：:Lipoprotein-Associated Coagulation Inhibitor (LACI) is a factor Xa dependent inhibitor of the factor VII(a)/Tissue Factor catalytic complex. Deduced from partial cDNA sequence, LACI's amino acid sequence has recently been reported. Northern blot analysis showed LACI cDNA hybridizes to RNAs of 1.4 and 4.0 kb in size. T...

journal_title：Thrombosis research

authors： Girard TJ,Warren LA,Novotny WF,Bejcek BE,Miletich JP,Broze GJ Jr

更新日期：1989-07-01 00:00:00

abstract：:To estimate the effect of dilazep in preventing restenosis after a transluminal angioplasty, we have attempted an animal experiment in which the efficacy of drug was tested on an angioplastic injury superimposed on to atherosclerotic lesions. Using a modification of Block's method, atherosclerotic lesions first were m...

journal_title：Thrombosis research

authors： Nobuyoshi M,Tanaka M,Fujii M,Asanuma A,Takimoto M

更新日期：1989-06-15 00:00:00

abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...

journal_title：Thrombosis research

authors： Sloand EM,Kessler CM,McIntosh CL,Klein HG

更新日期：1989-06-15 00:00:00

abstract：:Properties of a new concentrate of FVII/FVIIa, obtained by adsorption onto an inorganic adsorbent followed by a chromatographic step onto Q-Sepharose using a by-product of routine fractionation as starting material, are described. This fraction contains only small amounts of the other components of the prothrombin com...

journal_title：Thrombosis research

authors： Chabbat J,Hampikian-Lenin S,Toully V,Gaillandre A,Péjaudier L,Steinbuch M

更新日期：1989-06-15 00:00:00

abstract：:Antithrombotic activity of ten pyrazolo pyrimidine derivatives was tested in mouse pulmonary thromboembolism model. Out of these compounds, Thiopurinol (C5H4N4S) showed dose-dependent protection in mice from death/paralysis induced by collagen + adrenaline. It also caused dose-dependent inhibition of thrombus formatio...

journal_title：Thrombosis research

authors： Srivastava R,Mishra A,Pratap R,Bhakuni DS,Srimal RC

更新日期：1989-06-15 00:00:00

abstract：:Analogs of the antithrombin peptide hirudin54-65 with C-terminal modifications have been synthesized in order to examine the requirements for alpha-thrombin inhibition. The C-terminal residue, Gln65, could be replaced with L-amino acids or amino alcohols with neutral or charged hydrophilic side chains without greatly ...

journal_title：Thrombosis research

authors： Krstenansky JL,Payne MH,Owen TJ,Yates MT,Mao SJ

更新日期：1989-05-15 00:00:00

abstract：:Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion...

journal_title：Thrombosis research

authors： Lawrence JB,Prevosti LG,Kramer WS,Lu DY,Leon MB

更新日期：1989-04-15 00:00:00

abstract：:Intimal proliferation of smooth muscle cells is an important characteristic of developing atherosclerotic lesions and late occlusion of venous bypass grafts. Platelet-derived growth factor, released from aggregating platelets at sites of endothelial injury, has been suggested as a main factor responsible for intimal h...

journal_title：Thrombosis research

authors： Nilsson J,Elgue G,Wallin M,Hamsten A,Blombck M

更新日期：1989-04-15 00:00:00

abstract：:High molecular weight kininogen has been shown to be the principal plasma inhibitor of cellular thiol proteases including cathepsins B, H and L and calpains 1 and 2. Since these same enzymes have been reported to be elevated in animals with muscular dystrophy, we studied plasmas from hamsters with muscular dystrophy a...

journal_title：Thrombosis research

authors： Colman RW,Bradford HN,Warner AH

更新日期：1989-04-15 00:00:00

abstract：:We report an inbred family with two cases of homozygous protein C deficiency and review 11 other such cases. Both patients presented in the second half of their first year of life with recurrent rapidly disappearing ecchymotic skin lesions, disseminated intravascular coagulation, and venous thrombosis. Successful trea...

journal_title：Thrombosis research

authors： Tuddenham EG,Takase T,Thomas AE,Awidi AS,Madanat FF,Abu Hajir MM,Kernoff PB,Hoffbrand AV

更新日期：1989-03-01 00:00:00

abstract：:Collagen-induced platelet aggregation and secretion (ATP-release) in whole-blood and platelet-rich plasma was compared. Although the amount of ATP released was comparable in whole-blood and platelet-rich plasma, the maximum extent of aggregation was greater when platelets were studied in their natural milieu, i.e. who...

journal_title：Thrombosis research

authors： Joseph R,Welch KM,D'Andrea G,Riddle JM

更新日期：1989-03-01 00:00:00

abstract：:Ten studies of the effect of cryoprecipitate infusion in four patients with von Willebrand's Disease (vWD) are reported. The doses studied (4, 8 and in one case 10 bags of cryoprecipitate) were based on previous reports of correction of the bleeding time (BT) with such doses. A modest shortening of the BT was observed...

journal_title：Thrombosis research

authors： Smiley RK,Tittley P,Rock G

更新日期：1989-03-01 00:00:00

abstract：:Three commercial thrombin preparations used clinically to stop topical bleeding were studied. The specific activities of these preparations were 1,064 U/mg (human); 59 U/mg (bovine) and 147 U/mg (bovine). SDS-PAGE analysis of the human product produced one major band corresponding to a molecular weight of alpha-thromb...

journal_title：Thrombosis research

authors： Suzuki S,Sakuragawa N

更新日期：1989-02-01 00:00:00

abstract：:We have investigated the role of platelet activating factor (PAF) in the pathogenesis of a murine model of traumatic shock using WEB 2086, a specific antagonist of PAF. WEB 2086 (0.5 mg/kg) significantly reversed the decrease in mean arterial blood pressure (MABP) induced by PAF (0.3 micrograms/kg) in anesthetized rat...

journal_title：Thrombosis research

authors： Stahl GL,Bitterman H,Lefer AM

更新日期：1989-02-01 00:00:00

abstract：:Ca2+ influx and efflux in unstimulated platelets and Ca2+ uptake by simultaneously isolated two membrane fractions of platelets from patients with myeloproliferative disorders (MPD) have been investigated. In MPD, Ca2+ influx and efflux across the plasma membrane in unstimulated platelets were in equilibrium at signif...

journal_title：Thrombosis research

authors： Fujimoto T,Fujimura K,Kuramoto A

更新日期：1989-01-15 00:00:00

abstract：:Human platelets contain a single membrane glycoprotein which is susceptible to thrombin proteolysis, glycoprotein V. We have purified 1 mg of glycoprotein V from 10(13) platelets using a combination of gel filtration, hydroxylapatite and ion-exchange chromatographies. Glycoprotein V has a blocked amino-terminus. Follo...

journal_title：Thrombosis research

authors： Zafar RS,Walz DA

更新日期：1989-01-01 00:00:00

abstract：:The effects of ticlopidine treatment (250 mg b.i.d. for 21 months) on fibrinogen and other rheological variables, as compared to placebo, were studied in 44 patients with intermittent claudication due to peripheral arterial occlusive disease. Blood samples were collected every 3 months during this double-blind, random...

journal_title：Thrombosis research

authors： Palareti G,Poggi M,Torricelli P,Balestra V,Coccheri S

更新日期：1988-12-15 00:00:00

abstract：:Fibrin film is prepared by compaction in one dimension of a fibrin clot (pH 6.3, ionic strength 0.15, fibrin concentration about 0.5%) by expulsion of fluid to reach a fibrin concentration of about 15%. Strips of film, equilibrated in the same buffer with very slowly increasing temperature, shrink in length in a narro...

journal_title：Thrombosis research

authors： Nakatani AI,Ferry JD

更新日期：1988-12-01 00:00:00

abstract：:The thrombolytic efficacy of recombinant tissue-type plasminogen activator (tPA) in the presence and absence of a thromboxane synthase inhibitor was studied in a model of femoral artery thrombosis in the anesthetized rabbit. The thrombus was formed by injection of thrombin and whole blood into an isolated segment of t...

journal_title：Thrombosis research

authors： Shebuski RJ,Storer BL,Fujita T

更新日期：1988-12-01 00:00:00

abstract：:The in vitro and in vivo pharmacological properties of two oversulfated dermatan sulfate (DS) derivatives, S-DS1 and S-DS2, containing 2 and 3.7 sulfate groups/disaccharide unit respectively were compared to those of the parent DS (1 sulfate group/disaccharide unit). In a purified system the ability of S-DS1 and of S-...

journal_title：Thrombosis research

authors： Dol F,Caranobe C,Dupouy D,Petitou M,Lormeau JC,Choay J,Sié P,Boneu B

更新日期：1988-10-15 00:00:00

abstract：:RS-5186, sodium 6-[2-[1-(1H)-imidazolyl]methyl-4,5-dihydrobenzo[b]thiophene]- carboxylate, inhibited platelet thromboxane A2 (TXA2) synthetase with IC50 values of 6 nM and 13 nM for human and rabbit microsomes, respectively. It had a selectivity for TXA2 synthetase 10(5)-fold greater than that for cyclooxygenase, PGI2...

journal_title：Thrombosis research

authors： Ushiyama S,Ito T,Asai F,Oshima T,Terada A,Matsuda K,Yamazaki M

更新日期：1988-09-01 00:00:00

abstract：:The effects and mechanism of action of a phospholipase C (PLC) from Pseudomonas aeruginosa on human platelet rich plasma were examined to better understand the interaction of PLC with human platelets. PLC caused platelet aggregation in a concentration-dependent manner. Enzymatic activity of PLC was necessary for aggre...

journal_title：Thrombosis research

authors： Coutinho IR,Berk RS,Mammen E

更新日期：1988-09-01 00:00:00

abstract：:The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was labelled with 125I and used as a standard for each experiment. Various tPA...

journal_title：Thrombosis research

authors： Beebe DP,Aronson DL

更新日期：1988-07-01 00:00:00

abstract：:Dextran sulfate and polybrene were immobilized on polypropylene tubes with plastic adhesive. Serum albumin was also immobilized on the tube by heat-denaturation. In the those tubes thrombin was protected from inactivation in the presence of 0.1 M NaCl remarkably. Cholesterol coated on the tube also protected the enzym...

journal_title：Thrombosis research

authors： Oshima G

更新日期：1988-07-01 00:00:00

abstract：:Platelet and clotting abnormalities have been described in diabetes, but little is known about their relationship to daily stresses. In order to evaluate whether states of abnormal carbohydrate metabolism modify the hemostatic response to stress, 12 subjects with type I diabetes mellitus, 9 with type II, 7 with impair...

journal_title：Thrombosis research

authors： Maiello M,Boeri D,Bonadonna R,Odetti P,Saccarello A,Adezati L

更新日期：1988-06-15 00:00:00